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KMID : 1151920210030020064
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Chronobiology in Medicine
2021 Volume.3 No. 2 p.64 ~ p.69
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KL-6 in Obstructive Sleep Apnea: A Potential Biomarker of Subclinical Lung Injury
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Kim Sei-Won
Kim Hwan-Hee
Lee Hea-Yon
Kim In-Kyoung
Lee Sang-Haak
Kang Hyeon-Hui
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Abstract
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Objective: The relationship between obstructive sleep apnea (OSA) and cardiovascular diseases has been reported in several studies. However, little is known about the effects of OSA on pathophysiological processes in the lung. This study examined the association between OSA and serum levels of Krebs von den Lungen-6 (KL-6), which may reflect the degree of subclinical lung injury, according to the severity of OSA.
Methods: Forty adults who were diagnosed with OSA using type 1 polysomnography were included in this study. Patients with pulmonary diseases, cardiovascular diseases except well-controlled hypertension, or other significant medical conditions were excluded.
Results: Of the 40 patients with OSA, 10 had mild OSA [5≤apnea?hypopnea index (AHI)<15), and 30 had moderate-to-severe OSA (AHI≥15). There were no significant differences in gender, age, smoking history, body mass index, neck circumference, and waist circumference between those with mild and those with moderate-to-severe OSA. The median serum level of KL-6 differed significantly between the mild and moderate-to-severe OSA groups [180.8 (135.3, 213.8) vs. 281.5 (171.3, 410.6) U/mL, p=0.018]. After multiple regression analysis, the final model showed that smoking amount (beta=2.626, p=0.012) and AHI≥15 (beta=2.256, p=0.031) were significant predictors of KL-6.
Conclusion: Serum KL-6 levels were significantly elevated in moderate-to-severe OSA compared with mild OSA, independent of smoking and other factors. OSA is associated with lung injury, and KL-6 shows potential as a clinical biomarker.
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KEYWORD
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Obstructive sleep apnea, Krebs von den Lungen-6, Lung injury, Hypoxia, Biomarker
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